PERSONALIZED NUTRITION AND ARTIFICIAL INTELLIGENCE: MODERN APPROACHES, REGULATORY CHALLENGES, AND CLINICAL EFFICACY

Authors

  • Zinaida Burova National University of Life and Environmental Sciences of Ukraine image/svg+xml Author
  • Maksym Hudzenko National University of Life and Environmental Sciences of Ukraine image/svg+xml Author
  • Yuliia Kryzhova National University of Life and Environmental Sciences of Ukraine image/svg+xml Author
  • Denіs Gaiduchek National University of Food Technologies image/svg+xml Author

DOI:

https://doi.org/10.31548/humanhealth.3.2026.67

Keywords:

precision diet, machine learning, deep learning, microbiome analysis, metabolic biomarkers, explainable artificial intelligence

Abstract

The digitalization of healthcare is driving a shift from generalized dietary models to personalized nutrition. Traditional approaches fail to account for individual metabolic variations, which reduces their effectiveness in chronic disease prevention. The objective of this paper is to analyze artificial intelligence systems in generating personalized dietary recommendations, evaluate their clinical efficacy, address data standardization challenges, and explore ethical implementation aspects. The study employs a systematic review of scientific sources, a comparative analysis of clinical trials—specifically randomized controlled trials—and conceptual modeling of the operational data flow. It was established that dietary personalization operates as a dynamic 5-step loop: multimodal data collection, AI-driven analysis, prediction, recommendation generation, and real-time feedback. Certain artificial intelligence models (XGBoost, Stacking) demonstrated a metabolic risk prediction accuracy of up to 96.07%. Dietary assessment utilizing computer vision and deep learning improves food recognition accuracy by 30% when accounting for national context and geolocation.

Clinical data confirm that dietary recommendations developed using artificial intelligence models achieve a 39% reduction in irritable bowel syndrome symptoms and a 72.7% diabetes type 2 remission rate. Thus, the efficacy of incorporating artificial intelligence technologies into personalized recommendations for health improvement and symptom reduction in chronic diseases has been proven, with results demonstrating significant enhancements in patients' metabolic parameters and life quality.

The necessity of data standardization and regulatory framework development for the successful implementation of personalized nutrition into clinical practice is also emphasized. Ethical issues regarding privacy and accountability in AI applications are highlighted, alongside the importance of explainable artificial intelligence in fostering patient trust in digital health solutions. Ultimately, the prospects for personalized nutrition as a new paradigm in dietary science with the potential to substantially improve public health and well-being approaches are outlined.

Received 12.07.2026, accepted  21.08.2026, published 22.06.2026

References

Abbas, Q., Jeong, W., & Lee, S. W. (2025). Explainable AI in Clinical Decision Support Systems: A Meta-Analysis of Methods, Applications, and Usability Challenges. Healthcare, 13(17), 2154. https://doi.org/10.3390/healthcare13172154

Agrawal, K., Goktas, P., Kumar, N., & Leung, M.-F. (2025). Artificial intelligence in personalized nutrition and food manufacturing: A comprehensive review of methods, applications, and future directions. Frontiers in Nutrition, 12, Article 1636980. https://doi.org/10.3389/fnut.2025.1636980

Andrade-Calle, R., de la Torre-Díez, I., & de Luis-Román, D. (2025). Predictive Modeling of Weight Loss and Metabolic Health Outcomes: A Retrospective Predictive Modeling Study. Health Science Reports, 8(10), e71236. https://doi.org/10.1002/hsr2.71236

Brankovic, A., & Hendrie, G. A. (2025). Perspectives, challenges and future of artificial intelligence in personalised nutrition research. Proceedings of the Nutrition Society, 84(4), 1–9. https://doi.org/10.1017/S0029665125100657

Chotwanvirat, P., Prachansuwan, A., Sridonpai, P., & Kriengsinyos, W. (2024). Advancements in Using AI for Dietary Assessment Based on Food Images: Scoping Review. Journal of Medical Internet Research, 26, e51432. https://doi.org/10.2196/51432

Chudyk, N. (2024). Ethical and legal aspects of artificial intelligence systems implementation: Balancing technological progress and fundamental human rights in the context of society’s digital transformation. Actual Problems of Law, 3, 42–47. https://doi.org/10.35774/app2024.03.042

Detopoulou, P., Voulgaridou, G., Moschos, P., & Papadopoulou, S. K. (2023). Artificial intelligence, nutrition, and ethical issues: A mini-review. Clinical Nutrition Open Science, 50, Article 100570. https://doi.org/10.1016/j.nutos.2023.07.001

EuroFIR. (n.d.). Retrieved November 11, 2025, from https://www.eurofir.org/

Fernandes, G. J., Choi, A., Schauer, J. M., Pfammatter, A. F., Spring, B. J., Darwiche, A., & Alshurafa, N. I. (2023). An Explainable Artificial Intelligence Software Tool for Weight Management Experts (PRIMO): Mixed Methods Study. Journal of Medical Internet Research, 25, e42047. https://doi.org/10.2196/42047

Fonseca, D. C., Fernandes, G. da R., & Waitzberg, D. L. (2025). Artificial intelligence and human microbiome: A brief narrative review. Clinical Nutrition Open Science, 59, 134–142. https://doi.org/10.1016/j.nutos.2024.12.009

FoodData Central. USDA’s comprehensive source of food composition data with multiple distinct data types. (n.d.) Retrieved November 11, 2025, from https://fdc.nal.usda.gov/

Gaiduchek, D., Kryvoplias-Volodina, L., Kostin, V., Burova, Z., & Zaporozhets, O. (2025). Synthesis of an analytical system prototype using MQTT and AWS in the Industry 4.0 context. CEUR Workshop Proceedings, 4146, 487–497. https://www.scopus.com/pages/publications/105037230065?

origin=resultslist

Gavai, A. K., & van Hillegersberg, J. (2025). AI-driven personalized nutrition: RAG-based digital health solution for obesity and type 2 diabetes. PLOS Digital Health, 4(5), e0000758. https://doi.org/10.1371/journal.pdig.0000758

Li, Z., Wu, W., & Kang, H. (2024). Machine Learning-Driven Metabolic Syndrome Prediction: An International Cohort Validation Study. Healthcare, 12(24), 2527. https://doi.org/10.3390/healthcare12242527

Liu, D., Zuo, E., Wang, D., He, L., Dong, L., & Lu, X. (2025). Deep Learning in Food Image Recognition: A Comprehensive Review. Applied Sciences, 15(14), 7626. https://doi.org/10.3390/app15147626

Mansouri, M., Benabdellah Chaouni, S., Jai Andaloussi, S., & El Aachak, O. (2023). Deep Learning for Food Image Recognition and Nutrition Analysis Towards Chronic Diseases Monitoring: A Systematic Review. SN Computer Science, 4(513). https://doi.org/10.1007/s42979-023-01972-1

Martynchuk, O., Bal-Prylypko, L., Shvets, O., & Altanova, A. (2025). Potential applicationts of artificial intelligence in nutrition science. Human and Nation’s Health, 3(1), 100–125. https://doi.org/10.31548/humanhealth.1.2025.100

Panayotova, G. G. (2025). Artificial Intelligence in Nutrition and Dietetics: A Comprehensive Review of Current Research. Healthcare, 13(20), 2579. https://doi.org/10.3390/healthcare13202579

Rafie, Z., Talab, M. S., Koor, B. E. Z., Garavand, A., Salehnasab, C., & Ghaderzadeh, M. (2025). Leveraging XGBoost and explainable AI for accurate prediction of type 2 diabetes. BMC Public Health, 25(1), Article 3688. https://doi.org/10.1186/s12889-025-24953-w

Romero-Tapiador, S., Lacruz-Pleguezuelos, B., Tolosana, R., Freixer, G., et al. (2023). AI4FoodDB: A database for personalized e-Health nutrition and lifestyle through wearable devices and artificial intelligence. Database: The Journal of Biological Databases and Curation, 2023, baad049. https://doi.org/10.1093/database/baad049

SAP. (n.d.). How to implement responsible AI practices. Retrieved November 11, 2025, from https://www.sap.com/ukraine/products/artificial-intelligence/ai-ethics.html

Verma, M., Hontecillas, R., Tubau-Juni, N., Abedi, V., & Bassaganya-Riera, J. (2018). Challenges in Personalized Nutrition and Health. Frontiers in Nutrition, 5, Article 117. https://doi.org/10.3389/fnut.2018.00117

Wang, L., Wang, X., Chen, A., Jin, X., & Che, H. (2020). Prediction of Type 2 Diabetes Risk and Its Effect Evaluation Based on the XGBoost Model. Healthcare, 8(3), 247. https://doi.org/10.3390/healthcare8030247

Wang, X., Sun, Z., Xue, H., & An, R. (2025). Artificial Intelligence Applications to Personalized Dietary Recommendations: A Systematic Review. Healthcare, 13(12), 1417. https://doi.org/10.3390/healthcare13121417

Wu, X., Oniani, D., Shao, Z., Arciero, P., Sivarajkumar, S., Hilsman, J., Mohr, A. E., Ibe, S., Moharir, M., Li-Jia Li, Jain, R., Chen, J., & Wang, Y. (2025). A Scoping Review of Artificial Intelligence for Precision Nutrition. Advances in Nutrition, 16(4), 100398. https://doi.org/10.1016/j.advnut.2025.100398

Yang, C. C. (2022). Explainable Artificial Intelligence for Predictive Modeling in Healthcare. Journal of Healthcare Informatics Research, 6, 228–239. https://doi.org/10.1007/s41666-022-00114-1

Yao, Y., Duan, J., Xu, K., Cai, Y., Sun, Z., & Zhang, Y. (2024). A survey on large language model (LLM) security and privacy: The good, the bad, and the ugly. High-Confidence Computing, 4(2), 100211. https://doi.org/10.1016/j.hcc.2024.100211

Zale, A., & Mathioudakis, N. (2022). Machine Learning Models for Inpatient Glucose Prediction. Current Diabetes Reports, 22, 353–364. https://doi.org/10.1007/s11892-022-01477-w

Published

2026-09-02

Issue

Section

Food technologies

How to Cite

Burova, Z., Hudzenko, M., Kryzhova, Y., & Gaiduchek, D. (2026). PERSONALIZED NUTRITION AND ARTIFICIAL INTELLIGENCE: MODERN APPROACHES, REGULATORY CHALLENGES, AND CLINICAL EFFICACY. Human and Nation’s Health, 4(3), 67-81. https://doi.org/10.31548/humanhealth.3.2026.67

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